反应详情

温度

50 °C

Hydroxyacetic acid tert-butyl ester (70 mg) and sodium hydride (60%; 21 mg) were added to a solution of the compound obtained in Example 21 (1) above (200 mg) in tetrahydrofuran (3 ml) and the mixture was stirred at 50° C. for an hour. The reaction mixture was cooled to room temperature, a saturated sodium hydrogen carbonate aqueous solution and ethyl acetate were added and the organic layer was separated, washed with a saturated brine, dried over magnesium sulfate and concentrated in vacuo. The resulting residue was purified by column chromatography (NH-silica gel; hexane:ethyl acetate=9:1→3:2) to give the titled compound (183 mg). MS (m/z): 566 [M+H]+.

1. temperatureThe reaction mixture was cooled to room temperature
2. customthe organic layer was separated
3. washwashed with a saturated brine
4. dry with materialdried over magnesium sulfate
5. concentrationconcentrated in vacuo
6. customThe resulting residue was purified by column chromatography (NH-silica gel; hexane:ethyl acetate=9:1→3:2)