Potassium Hydroxide → 7,10-Dihydro-4,10-dioxo-2-methyl-7-propynyl-4H-furo[3',2': 3,4]-cyclohepta[1,2-b]pyridine-6-carboxylic Acid

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Reaction Steps

A mixture of 7,10-dihydro-4,10-dioxo-2-methyl-7-propynyl-4H-furo[3',2': 3,4]cyclohepta[1,2-b]pyridine-6-carboxylic acid ethyl ester (1.2 g, described in Example 24), 1N potassium hydroxide (4 ml) and water (6 ml) is stirred at room temperature for 16 hr. The precipitate is removed and the solution is acidified with 10% hydrochloric acid. The precipitate is collected, washed with water and crystallized from pyridine to obtain crystals of the title compound, mp 237°-238° C.

Provenance & Evidence