1-Pyrrolidineethanamine → HCID 59376055, compound

HRID 661497Notes

Reaction equation

HRID 661497 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:5](=[O:14])[CH2:6][CH2:7][CH2:8][C:9]=2[C:10]=1[C:11]([OH:13])=O.[N:15]1([CH2:20][CH2:21][NH2:22])[CH2:19][CH2:18][CH2:17][CH2:16]1>>[CH3:1][C:2]1[NH:3][C:4]2[C:5](=[O:14])[CH2:6][CH2:7][CH2:8][C:9]=2[C:10]=1[C:11]([NH:22][CH2:21][CH2:20][N:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1)=[O:13]

Participants

3

Reactant 2

HCID 13441-PyrrolidineethanamineHCID 59376005HCID 59376005, compound

Product 1

HCID 59376055HCID 59376055, compoundYield 73%

Procedure

Similar procedure as Example 2, 2-methyl-7-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylic acid (S4) 0.2 g (1.0 mmol) and 2-(pyrrolidin-1-yl)ethanamine 0.24 g (2.1 mmol) was reacted to give 0.21 g (73%) of the titled compound as a white solid.

Sources & evidence

ORD record
ord-c1d9e31e8af94b23b19b716599f5499a
Source dataset
uspto-grants-2011_12
Patent number
US08084621B2

Reaction notes

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