N,N-Diethyl-1,3-propanediamine → HCID 59376081, compound

HRID 661499Notes

Reaction equation

HRID 661499 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:5](=[O:14])[CH2:6][CH2:7][CH2:8][C:9]=2[C:10]=1[C:11]([OH:13])=O.[CH2:15]([N:17]([CH2:22][CH3:23])[CH2:18][CH2:19][CH2:20][NH2:21])[CH3:16]>>[CH2:15]([N:17]([CH2:22][CH3:23])[CH2:18][CH2:19][CH2:20][NH:21][C:11]([C:10]1[C:9]2[CH2:8][CH2:7][CH2:6][C:5](=[O:14])[C:4]=2[NH:3][C:2]=1[CH3:1])=[O:13])[CH3:16]

Participants

3

Reactant 2

HCID 61011N,N-Diethyl-1,3-propanediamineHCID 59376005HCID 59376005, compound

Product 1

HCID 59376081HCID 59376081, compoundYield 85.1%

Procedure

Similar procedure as Example 2, 2-methyl-7-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylic acid (S4) 0.2 g (1.0 mmol) and N1,N1-diethylpropane-1,3-diamine 0.27 g (2.1 mmol) was reacted to give 0.26 g (85%) of the titled compound as a white solid.

Sources & evidence

ORD record
ord-f959ce06b39a459d9ba2e688b6ae73b2
Source dataset
uspto-grants-2011_12
Patent number
US08084621B2

Reaction notes

Loading…