1-(3-Aminopropyl)-4-methylpiperazine → HCID 59376023, compound

HRID 661501Notes

Reaction equation

HRID 661501 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:5](=[O:14])[CH2:6][CH2:7][CH2:8][C:9]=2[C:10]=1[C:11]([OH:13])=O.[CH3:15][N:16]1[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][CH2:24][NH2:25])[CH2:18][CH2:17]1>>[CH3:1][C:2]1[NH:3][C:4]2[C:5](=[O:14])[CH2:6][CH2:7][CH2:8][C:9]=2[C:10]=1[C:11]([NH:25][CH2:24][CH2:23][CH2:22][N:19]1[CH2:18][CH2:17][N:16]([CH3:15])[CH2:21][CH2:20]1)=[O:13]

Participants

3

Reactant 2

HCID 783281-(3-Aminopropyl)-4-methylpiperazineHCID 59376005HCID 59376005, compound

Product 1

HCID 59376023HCID 59376023, compoundYield 78.2%

Procedure

Similar procedure as Example 2, 2-methyl-7-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylic acid (S4) 0.2 g (1.0 mmol) and 3-(4-methylpiperazin-1-yl)propan-1-amine 0.33 g (2.1 mmol) was reacted to give 0.26 g (78%) of the titled compound as a white solid.

Sources & evidence

ORD record
ord-a5c0abccdf56445ba917b175047692a6
Source dataset
uspto-grants-2011_12
Patent number
US08084621B2

Reaction notes

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