HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Amino-3-(pyrrolidin-1-yl)propan-2-ol → N-(2-hydroxy-3-(pyrrolidin-1-yl)propyl)-2-methyl-7-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Amino-3-(pyrrolidin-1-yl)propan-2-ol | HCID 12174993 | — |
| Reactant | HCID 59376005 | HCID 59376005 | — |
| Product | N-(2-hydroxy-3-(pyrrolidin-1-yl)propyl)-2-methyl-7-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | HCID 59376045 | 82% |
Reaction Steps
Similar procedure as Example 13, 2-methyl-7-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylic acid (S4) 0.2 g (1.0 mmol) and 1-amino-3-(pyrrolidin-1-yl)propan-2-ol 0.30 g (2.1 mmol) was reacted to give 0.26 g (82%) of the titled compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08084621B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-c4c01c70c91f4a9bb353f523c3e2d439 |
| Source note | uspto-grants-2011_12 |