HCID 16785613, compound → HCID 59375999, compound

HRID 661508Notes

Reaction equation

HRID 661508 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:5](=[O:14])[CH2:6][CH2:7][CH2:8][C:9]=2[C:10]=1[C:11]([OH:13])=O.[NH2:15][CH2:16][CH:17]([OH:27])[CH2:18][N:19]([CH:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1)[CH3:20]>>[CH:21]1([N:19]([CH3:20])[CH2:18][CH:17]([OH:27])[CH2:16][NH:15][C:11]([C:10]2[C:9]3[CH2:8][CH2:7][CH2:6][C:5](=[O:14])[C:4]=3[NH:3][C:2]=2[CH3:1])=[O:13])[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 16785613HCID 16785613, compoundHCID 59376005HCID 59376005, compound

Product 1

HCID 59375999HCID 59375999, compoundYield 83%

Procedure

Similar procedure as Example 13, 2-methyl-7-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylic acid (S4) 0.2 g (1.0 mmol) and 1-amino-3-(cyclohexyl(methyl)amino)propan-2-ol 0.39 g (2.1 mmol) were reacted to give 0.30 g (83%) of the titled compound as a white solid.

Sources & evidence

ORD record
ord-4195edd5c6154d62856d4b72dc3ca651
Source dataset
uspto-grants-2011_12
Patent number
US08084621B2

Reaction notes

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