Potassium Carbonate → HCID 59370337, compound

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	5-Bromo-2-chloropyridine	HCID 2734414	—
Reactant	4-chloro-N-(2-methoxy-phenyl)-N-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzamide	HCID 68602628	—
Catalyst	HCID 178418397	HCID 178418397	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	HCID 59370337	HCID 59370337	—

Reaction Conditions

Temperature	100 °C

Reaction Steps

A mixture of 4-chloro-N-(2-methoxy-phenyl)-N-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzamide (60 mg, 0.15 mmol), 5-bromo-2-chloro-pyridine (29 mg, 0.15 mmol), Pd(PPh3)4 (12 mg, 0.01 mmol), K2CO3 (41 mg, 0.3 mmol) in dioxane (1 mL), was heated at 100° C. for 12 hrs. The mixture was filtered and purified by prep. LCMS to yield 4-chloro-3-(6-chloro-pyridin-3-yl)-N-(2-methoxy-phenyl)-N-methyl-benzamide 2-1.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08084614B2
Source dataset	uspto-grants-2011_12
ORD ID	ord-9967f5881ce4443e86e884f58134811f
Source note	uspto-grants-2011_12