HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 661706Generated: November 1, 2026
Potassium Carbonate → (S)-1-(3-hydroxy-propyl)-pyrrolidine-2-carboxylic acid tert-butyl ester
https://huagongshe.com/reaction/661706
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Bromo-1-propanol | HCID 12308 | — |
| Reactant | L-Proline 1,1-dimethylethyl ester | HCID 6453108 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | (S)-1-(3-hydroxy-propyl)-pyrrolidine-2-carboxylic acid tert-butyl ester | HCID 68602721 | 94.9% |
Reaction Steps
To a solution of (S)-pyrrolidine-2-carboxylic acid tert-butyl ester (350 mg, 2.04 mmol) in CH3CN (5 mL), 3-bromo-propan-1-ol (268 μL, 3.06 mmol) and K2CO3 (844 mg, 6.12 mmol) were added. The mixture was heated at 85° C. overnight, concentrated and purified by silica gel column chromatography (DCM/MeOH=95/5) to afford 444 mg (S)-1-(3-hydroxy-propyl)-pyrrolidine-2-carboxylic acid tert-butyl ester. MS: 230.2 (M+H)+, tR=0.99 min (method 1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08084614B2 |
|---|
| Source dataset | uspto-grants-2011_12 |
|---|
| ORD ID | ord-b40bdd2a29d94f808fa0a89165f72a48 |
|---|
| Source note | uspto-grants-2011_12 |
|---|
