反应详情

温度

50 °C

N-phenyl-3-(phenylthio)acrylamide (2.0 g) was dissolved to chloroform (10 ml), and 7.8 ml of tetrafluoroboric acid triethyloxonium-dichloromethane 1 mol/L solution was added thereto dropwise under ice-cooling. It was stirred for one hour at room temperature, 50° C. for two hours and for five hours under heat refluxing. After cooling, ice-water was added to the reaction solution, then the chloroform layer was separated. The chloroform layer was washed with water, dried and distilled off the solvent. The residue was subjected to silica gel column chromatography (hexane/ethyl acetate=15/1) to obtain ethyl N-phenyl-3-(phenylthio)acrylimidate (0.15 g) as oil.

1. additionwas added
2. temperaturedropwise under ice-cooling
3. temperatureunder heat
4. temperaturerefluxing
5. temperatureAfter cooling
6. customthe chloroform layer was separated
7. washThe chloroform layer was washed with water
8. customdried
9. distillationdistilled off the solvent