HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-Dimethylphenyl isocyanate → 4-(3-(3-(3,4-Dimethylphenyl)ureido)-2-methylphenyl)-7-(4-methylpiperazine-1-carbonyl)-9h-carbazole-1-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-Dimethylphenyl isocyanate | HCID 4389663 | — |
| Reactant | 4-(3-amino-2-methylphenyl)-7-(4-methylpiperazine-1-carbonyl)-9H-carbazole-1-carboxamide | HCID 46833813 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(3-(3-(3,4-Dimethylphenyl)ureido)-2-methylphenyl)-7-(4-methylpiperazine-1-carbonyl)-9h-carbazole-1-carboxamide | HCID 46834102 | — |
Reaction Steps
A solution of 4-(3-amino-2-methylphenyl)-7-(4-methylpiperazine-1-carbonyl)-9H-carbazole-1-carboxamide (Example 3-2, 25 mg, 0.028 mmol) and TEA (8 μL, 0.057 mmol) in DCM (2 mL) was treated with 4-isocyanato-1,2-dimethylbenzene (8.33 mg, 0.057 mmol) and the mixture was stirred at rt overnight.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08084620B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-37f7d8e7d28b4e40ac13aaea47e95903 |
| Source note | uspto-grants-2011_12 |