Potassium Carbonate → HCID 178425614, compound

Participants

Reaction Conditions

Reaction Steps

Pd(OAc)2 (56.3 mg, 0.25 mmol), PPh3 (263.0 mg, 1.0 mmol), K2CO3 (1.7 g, 12.5 mmol) and 1,1-dimethylethyl [(3-bromo-4-cyanophenyl)methyl]carbamate (2.6 g, 8.4 mmol) were suspended in 1,4-dioxane (30 mL). After the mixture was heated to 80° C. for 15 min, [3-(hydroxymethyl)phenyl]boronic acid-(1,1-dimethylethyl)(trimethyl)silane (2.7 g, 10.0 mmol) was added. Then the reaction mixture was stirred over night at 100° C. After cooling to room temperature, the solvent was removed under reduced pressure. The residue was dissolved in CH2Cl2 (50 mL), washed with water (20 mL), brine (20 mL), and dried over Na2SO4. After the solvent was removed, the crude product was purified on Al2O3 column chomatography, eluting with CH2Cl2 to yield the captioned product (2.6 g, yield: 60%). 1H NMR (400 MHz, CDCl3) δ 0.12 (s, 6H), 0.95 (s 9H), 1.46 (s, 9H), 4.41-4.42 (m, 2H), 4.81 (s, 2H), 7.37-7.47 (m, 6H), 7.71 (d, J=8.0 Hz, 1H); 13C NMR (100 MHz, CDCl3) δ −5.3, 18.4, 25.9, 28.3, 44.2, 64.7, 80.0, 109.9, 118.6, 126.1, 126.2, 126.4, 127.3, 128.6, 134.0, 137.9, 142.0, 144.5, 145.8, 155.8; HPLC: retention time: 9.500 min; purity: 95.2% (HPLC).

Provenance & Evidence