反应详情

In a 50 ml glass liner charged 12.8 mg of platinum oxide dampened with acetic anhydride. 417.7 mgs of N,N'-diacetyldehydrobiotin methyl ester high in the 1-isomer were added. The mixture was diluted to 50 ml with acetic anhydride. Hydrogenation was carried out at 550 psi of H2, 85° C., for 6 hours. After cooling the mixture was filtered through Celite removing the Pt metal. Stripping of solvent yielded a colorless oil. Analysis showed ~20% of starting material and 80% of reduction product high in the 1-isomer proportional to that in the starting material.

1. temperatureAfter cooling the mixture
2. filtrationwas filtered through Celite
3. customremoving the Pt metal
4. customyielded a colorless oil