Hydrochloric Acid → HCID 68907177, compound

Participants

Reaction Steps

To a solution of N-({3′-[(1S,4S)-2,5-diazabicyclo[2.2.1]hept-2-ylmethyl]-6-methyl-3-biphenylyl}methyl)-N′-{[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-2,6-pyridinedicarboxamide (390 mg, 0.526 mmol) in ethanol 95 mL) was added 1N HCl (0.526 mL, 0.526 mmol). The mixture was stirred at RT for 2 h. It was concentrated under vacuum. The residue was re-dissolved in ethanol and it was evaporated (this was repeated three times). Then a 1:1 mixture of DCM:hexane (5 mL) was added and concentrated (this was repeated twice). Finally, the solid, a white material, was dried under high vacuum for two days to give N-({3′-[(1S,4S)-2,5-diazabicyclo[2.2.1]hept-2-ylmethyl]-6-methyl-3-biphenylyl}methyl)-N′-{[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}-2,6-pyridinedicarboxamide hydrochloride as a solid (404 mg, 99%). LC-MS m/z 742 (M+H)+, 0.79 min (ret time).

Provenance & Evidence