HRID66224

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID176

Acetic Acid

C2H4O2

HCID14798

Sodium Hydroxide

HNaO

结构：COC(=O)c1ccc(NS(=O)(=O)c2ccc3c(S(=O)(=O)Nc4ccc(C(=O)OC)cc4)cc(S(=O)(=O)Nc4ccc(C(=O)OC)cc4)cc3c2)cc1

HCID54080400

未命名化合物

PRODUCTS

生成物

结构：O=C([O-])c1ccc(NS(=O)(=O)c2ccc3c(S(=O)(=O)Nc4ccc(C(=O)[O-])cc4)cc(S(=O)(=O)Nc4ccc(C(=O)[O-])cc4)cc3c2)cc1.[Na+].[Na+].[Na+]

HCID70615223

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A 9.0 g portion of the product of Example 7 is dissolved in 46.5 ml of 2N sodium hydroxide and stirred for 45 minutes. The solution is neutralized with 2.7 ml of glacial acetic acid and diluted with 200 ml of ethanol. A yellow solid separates which is collected by filtration, washed with ethanol and ether, and dried to give 8.7 g of the product of the Example.

WORKUP

后处理

filtrationA yellow solid separates which is collected by filtration
washwashed with ethanol and ether
customdried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b5bd33d821ec408681a4b714a1fd00cb
来源数据集: uspto-grants-1978_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04130660
来源说明: uspto-grants-1978_12

反应 SMILES

C[O:2][C:3](=[O:52])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][S:11]([C:14]2[CH:15]=[C:16]3[C:21](=[CH:22][CH:23]=2)[C:20]([S:24]([NH:27][C:28]2[CH:37]=[CH:36][C:31]([C:32]([O:34]C)=[O:33])=[CH:30][CH:29]=2)(=[O:26])=[O:25])=[CH:19][C:18]([S:38]([NH:41][C:42]2[CH:51]=[CH:50][C:45]([C:46]([O:48]C)=[O:47])=[CH:44][CH:43]=2)(=[O:40])=[O:39])=[CH:17]3)(=[O:13])=[O:12])=[CH:6][CH:5]=1.C(O)(=O)C.[OH-].[Na+:58]>C(O)C>[Na+:58].[Na+:58].[Na+:58].[C:20]1([S:24]([NH:27][C:28]2[CH:37]=[CH:36][C:31]([C:32]([O-:34])=[O:33])=[CH:30][CH:29]=2)(=[O:26])=[O:25])[C:21]2[C:16](=[CH:15][C:14]([S:11]([NH:10][C:7]3[CH:8]=[CH:9][C:4]([C:3]([O-:52])=[O:2])=[CH:5][CH:6]=3)(=[O:12])=[O:13])=[CH:23][CH:22]=2)[CH:17]=[C:18]([S:38]([NH:41][C:42]2[CH:43]=[CH:44][C:45]([C:46]([O-:48])=[O:47])=[CH:50][CH:51]=2)(=[O:40])=[O:39])[CH:19]=1