HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 8-chloro-N-methyl-6-phenyl-4H-pyrazolo[1,5-a][1,4]benzodiazepine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 8-Chloro-6-phenyl-4H-pyrazolo[1,5-a][1,4]benzodiazepine-2-carboxylic acid, methyl ester | HCID 12377884 | — |
| Product | 8-chloro-N-methyl-6-phenyl-4H-pyrazolo[1,5-a][1,4]benzodiazepine-2-carboxamide | HCID 12377888 | — |
Reaction Steps
This compound was prepared from 1.48 g. (4.2 mmol) of the end product of Example 9 and mono-methylamine according to the procedure described above in Example 11. Recrystallization from acetone/ether/hexane gave the desired product, mp 170°-172°. An analytical sample was prepared by recrystallization from the same solvent system and isolated as colorless needles: mp 170°-172°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04130716 |
| Source dataset | uspto-grants-1978_12 |
| ORD ID | ord-e0099ad33cf449f99fbc106f7383a404 |
| Source note | uspto-grants-1978_12 |