4-Methoxypiperidine → 2,2,2-Trifluoro-1-[4-(4-methanesulfonyl-phenyl)-6-(4-methoxy-piperidin-1-yl)-2-methyl-quinolin-3-yl]-ethanone

HRID 662426Notes

Reaction equation

HRID 662426 reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:5](-[c:19]3[cH:20][cH:21][c:22]([S:25](=[O:26])(=[O:27])[CH3:28])[cH:23][cH:24]3)[c:6]([C:13]([C:14]([F:15])([F:16])[F:17])=[O:18])[c:7]([CH3:12])[n:8][c:9]2[cH:10][cH:11]1.[CH3:29][O:30][CH:31]1[CH2:32][CH2:33][NH:34][CH2:35][CH2:36]1>>[c:2]1([N:34]2[CH2:33][CH2:32][CH:31]([O:30][CH3:29])[CH2:36][CH2:35]2)[cH:3][c:4]2[c:5](-[c:19]3[cH:20][cH:21][c:22]([S:25](=[O:26])(=[O:27])[CH3:28])[cH:23][cH:24]3)[c:6]([C:13]([C:14]([F:15])([F:16])[F:17])=[O:18])[c:7]([CH3:12])[n:8][c:9]2[cH:10][cH:11]1

Participants

3

Reactant 2

HCID 776664-MethoxypiperidineHCID 115400851-[6-Bromo-4-(4-methanesulfonyl-phenyl)-2-methyl-quinolin-3-yl]-2,2,2-trifluoro-ethanone

Product 1

HCID 116778132,2,2-Trifluoro-1-[4-(4-methanesulfonyl-phenyl)-6-(4-methoxy-piperidin-1-yl)-2-methyl-quinolin-3-yl]-ethanone

Sources & evidence

ORD record
ord-4646412ceb104df58fd67795f8c8d03d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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