HuagongsheHuagongshe Chemistry Print Report · For research reference only
4'-Chloro-2-hydroxy-5-methylbenzophenone → 3-(4-Chlorophenyl)-5-methyl-isoindole-1-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4'-Chloro-2-hydroxy-5-methylbenzophenone | HCID 223485 | — |
| Reactant | {[2-Acetoxy-5-methyl-alpha-(4-chlorophenyl)benzyliden]-amino}malonic acid diethyl ester | HCID 54289668 | — |
| Reactant | HCID 136388433 | HCID 136388433 | — |
| Product | 3-(4-Chlorophenyl)-5-methyl-isoindole-1-carboxylic acid ethyl ester | HCID 54105506 | — |
Reaction Steps
The starting material, {[2-acetoxy-5-methyl-α-(4-chlorophenyl)benzyliden]-amino}malonic acid diethyl ester (colorless crystals from heptane, melting point 82°-84° C.), can be prepared as described in Example 1 from 4'-chloro-2-hydroxy-5-methyl-benzophenone via 4'-chloro-2-hydroxy-5-methyl-benzophenone imine (orange crystals from ethanol, melting point 134°-136° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04130717 |
| Source dataset | uspto-grants-1978_12 |
| ORD ID | ord-89bea5c73d0b49a48ec81de8bf98aca7 |
| Source note | uspto-grants-1978_12 |