HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 66250Generated: October 31, 2026
Allyl bromide → 2,6-Diethyl-2,3,6-trimethyl-1-(prop-2-en-1-yl)piperidine
https://huagongshe.com/reaction/66250
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Allyl bromide | HCID 7841 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2,6-Diethyl-2,3,6-trimethylpiperidine | HCID 20536078 | — |
| Solvent | 2,4,6-Tripropyl-2,6-dimethyl-1,2,5,6-tetrahydropyrimidine | HCID 22754574 | — |
| Product | 2,6-Diethyl-2,3,6-trimethyl-1-(prop-2-en-1-yl)piperidine | HCID 22754588 | — |
Reaction Steps
36.7 g of 2,6-diethyl-2,3,6-trimethylpiperidine and 30 g of allyl bromide are stirred for 7 days with heating at about 75° C. The reaction mixture is made alkaline by addition of 200 ml of 2 n sodium hydroxide and is extracted with ether. The ethereal solution is dried over K2CO3 and evaporated. The residue is purified by fractional distillation yielding 1-allyl-2,6-diethyl-2,3,6-trimethylpiperidine (Compound No. 4) which distills at 132°-135° C./16 mm Hg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04131599 |
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| Source dataset | uspto-grants-1978_12 |
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| ORD ID | ord-68ed29c4e365480f93dda058a115384a |
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| Source note | uspto-grants-1978_12 |
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