反应详情

A 19.35 g sample of 1-p-chlorophenyl-3-azabicyclo[3.1.0]hexane, 10.59 g of sodium carbonate and 17.5 g of p-chlorobenzoyl chloride are reacted in benzene. The benzene is evaporated and the dark purple residue is dissolved in 200 ml of chloroform and washed successively with 5% sodium carbonate, 0.5N hydrochloric acid and then with water and dried over sodium sulfate giving a dark purple oil. Addition of ether gives the product 3-p-chlorobenzoyl-1-(p-chlorophenyl)-3-azabicyclo[3.1.0]hexane as grey crystals, mp 98°-100° C.

1. customThe benzene is evaporated
2. dissolutionthe dark purple residue is dissolved in 200 ml of chloroform
3. washwashed successively with 5% sodium carbonate, 0.5N hydrochloric acid
4. dry with materialwith water and dried over sodium sulfate giving a dark purple oil
5. additionAddition of ether