反应详情

In a three-necked flask fitted with a Nichrome stirrer and a reflux condenser is placed 7.0 g of ethyl 3,4-dichlorophenylacetate, 5.9 g of N-bromosuccinimide, 0.1 g of benzoyl peroxide and 150 ml of carbon tetrachloride. The reaction mixture is heated at reflux for 18 hours, cooled and filtered. The carbon tetrachloride filtrate is concentrated under reduced pressure to give a deep orange liquid. Vacuum distillation at 115°-120° C. (0.5 mm) gives ethyl α-bromo-3,4-dichlorophenylacetate as a pale yellow liquid.

1. customIn a three-necked flask fitted with a Nichrome stirrer and a reflux condenser
2. temperatureThe reaction mixture is heated
3. temperatureat reflux for 18 hours
4. temperaturecooled
5. filtrationfiltered
6. concentrationThe carbon tetrachloride filtrate is concentrated under reduced pressure
7. customto give a deep orange liquid
8. distillationVacuum distillation at 115°-120° C. (0.5 mm)