4-(1-Pyrrolidinyl)piperidine → [5-Cyclopropyl-3-methyl-1-(4-trifluoromethoxy-phenyl)-1H-pyrazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone

HRID 663024Notes

Reaction equation

HRID 663024 reaction equation
[CH:1]1([c:4]2[c:5]([C:21](=[O:22])[OH:23])[c:6]([CH3:20])[n:7][n:8]2-[c:9]2[cH:10][cH:11][c:12]([O:15][C:16]([F:17])([F:18])[F:19])[cH:13][cH:14]2)[CH2:2][CH2:3]1.[N:24]1([CH:29]2[CH2:30][CH2:31][NH:32][CH2:33][CH2:34]2)[CH2:25][CH2:26][CH2:27][CH2:28]1>>[CH:1]1([c:4]2[c:5]([C:21](=[O:22])[N:32]3[CH2:31][CH2:30][CH:29]([N:24]4[CH2:25][CH2:26][CH2:27][CH2:28]4)[CH2:34][CH2:33]3)[c:6]([CH3:20])[n:7][n:8]2-[c:9]2[cH:10][cH:11][c:12]([O:15][C:16]([F:17])([F:18])[F:19])[cH:13][cH:14]2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 787034-(1-Pyrrolidinyl)piperidineHCID 673148045-Cyclopropyl-3-methyl-1-(4-trifluoromethoxy-phenyl)-1H-pyrazole-4-carboxylic acid

Product 1

HCID 57555046[5-Cyclopropyl-3-methyl-1-(4-trifluoromethoxy-phenyl)-1H-pyrazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone

Sources & evidence

ORD record
ord-78728400383d4f4f88867c38e9b2ba34
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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