3-phenyl-5-(beta-hydroxyphenethyl)-N-methyl-isoxazole-4-carboxamide → 5-methyl-6,7-dihydro-3,6-diphenyl isoxazolo[4,5-c]pyridin-4(5H)-one

Participants

Reaction Steps

To 550 ml. of polyphosphoric acid maintained at a temperature of 100° to 105° C. there is added 36.5 grams (0.114 moles) 3-phenyl-5-(β-hydroxyphenethyl)-N-methyl-isoxazole-4-carboxamide in portions. The mixture is then stirred at 100° for 5 hours and then poured onto 2 liters of ice and water. The resulting solid is filtered and purified by recrystallization to give 5-methyl-6,7-dihydro-3,6-diphenyl isoxazolo[4,5-c]pyridin-4-(5H)-one; m.p. 108° to 111° C.

Provenance & Evidence