HCID 13030891, compound → HCID 13030893, compound

HRID 66328Notes

Reaction equation

HRID 66328 reaction equation
[O:1]([CH2:8][CH:9]([OH:39])[CH2:10][NH:11][CH2:12][CH2:13][NH:14][C:15](=[O:38])[C:16]1[CH:21]=[C:20]([O:22]CC2C=CC=CC=2)[CH:19]=[CH:18][C:17]=1[O:30]CC1C=CC=CC=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O(CC(O)CNCCNC(=O)C1C=CC(OCC2C=CC=CC=2)=C(OCC2C=CC=CC=2)C=1)C1C=CC=CC=1>>[O:1]([CH2:8][CH:9]([OH:39])[CH2:10][NH:11][CH2:12][CH2:13][NH:14][C:15](=[O:38])[C:16]1[CH:21]=[C:20]([OH:22])[CH:19]=[CH:18][C:17]=1[OH:30])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 13030891HCID 13030891, compoundHCID 54217589HCID 54217589, compound

Product 1

HCID 13030893HCID 13030893, compound

Procedure

The process described in Example 12 is repeated except that 1-phenoxy-3-β-(2,5-dibenzyloxybenzamido)ethylamino-2-propanol (oxalate m.p. 176°-178° C.; prepared as described in Example 1 from β-(2,5-dibenzyloxybenzamido)ethylamine, m.p. 96°-98° C.) or 1-phenoxy-3-β-(3,4-dibenzyloxybenzamido)ethylamino-2-propanol (Example 6) is used as starting material. There are thus obtained respectively 1-phenoxy-3-β-(2,5-dihydroxybenzamido)ethylamino-2-propanol (hemioxalate m.p. 195°-197° C. after crystallisation from a mixture of ethanol and water), and 1-phenoxy-3-β-(3,4-dihydroxybenzamido)-ethylamino-2-propanol, m.p. 178°-180° C. after crystallisation from ethanol.

Sources & evidence

ORD record
ord-e4f6b54662dd49fb909415cae298f515
Source dataset
uspto-grants-1978_12
Patent number
US04131685

Reaction notes

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