Sulfuric Acid → 2-(4-Carbamylphenyl)oxazolo[5,4-b]pyridine

HRID 66369Notes

Reaction equation

HRID 66369 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:11]3[C:16]([N:17]=2)=[CH:15][CH:14]=[CH:13][N:12]=3)=[CH:5][CH:4]=1)#[N:2].S(=O)(=O)(O)[OH:19]>>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([C:9]2[O:10][C:11]3[C:16]([N:17]=2)=[CH:15][CH:14]=[CH:13][N:12]=3)=[CH:7][CH:8]=1)(=[O:19])[NH2:2]

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 124614172-(4-Cyanophenyl)oxazolo[5,4-b]pyridine

Product 1

HCID 227548262-(4-Carbamylphenyl)oxazolo[5,4-b]pyridine

Procedure

A solution of 600 mg. of 2-(4-cyanophenyl)oxazolo[5,4-b]pyridine in 8 ml. of concentrated sulfuric acid was allowed to stand at room temperature for 16 hours. The solution was poured onto ice and the white precipitate was collected on a filter to give 2-(4-carbamylphenyl)oxazolo[5,4-b]pyridine, m.p. 315° C. (dec.).

Workup

  1. additionThe solution was poured onto ice
  2. customthe white precipitate was collected on
  3. filtrationa filter

Sources & evidence

ORD record
ord-b9fe3b5e69554f7c8625f3bd6eee8ac0
Source dataset
uspto-grants-1978_12
Patent number
US04131677

Reaction notes

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