3-Methoxy-2-methyl-6-nitropyridine → 5-Methoxy-6-methylpyridin-2-amine

HRID 66374Notes

Reaction equation

HRID 66374 reaction equation
[CH3:1][O:2][C:3]1[C:4]([CH3:12])=[N:5][C:6]([N+:9]([O-])=O)=[CH:7][CH:8]=1>[Pd].CO>[NH2:9][C:6]1[N:5]=[C:4]([CH3:12])[C:3]([O:2][CH3:1])=[CH:8][CH:7]=1

Participants

4

Reactant 1

HCID 229239083-Methoxy-2-methyl-6-nitropyridine

Product 1

HCID 193743495-Methoxy-6-methylpyridin-2-amine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

3-Methoxy-2-methyl-6-nitropyridine (0.317 g.) in 20 ml. of methanol, was hydrogenated over 0.1 g. of 5% palladium-on-carbon catalyst. The catalyst was removed by filtration and the filtrate was concentrated to dryness to give 6-amino-3-methoxy-2-methylpyridine, which was used directly in the next step.

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated to dryness

Sources & evidence

ORD record
ord-eec27c9e560f49c7b7304c07e17a30ed
Source dataset
uspto-grants-1978_12
Patent number
US04131677

Reaction notes

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