3-oxazolo[4,5-b]pyridin-2-ylBenzonitrile → 2-[3-(Aminomethyl)phenyl]oxazolo[4,5-b]pyridine

Participants

Reaction Steps

A mixture of 2-(3-cyanophenyl)oxazolo[4,5-b]pyridine (2.2 g., 0.01 m.), 200 ml. of glacial acetic acid and 1.0 g. of PtO2 catalyst is reacted in a 40 p.s.i. hydrogen atmosphere at room temperature until the theoretical amount of hydrogen has been absorbed. The mixture is filtered, the acetic acid removed in vacuo to yield 2-[3-(aminomethyl)phenyl]oxazolo[4,5-b]pyridine.

Provenance & Evidence