4-Oxo-4-(3-pyridyl)butyric acid → 1-[3-(3-pyridylcarbonyl)propionyl]-L-proline

HRID 66485Notes

Reaction equation

HRID 66485 reaction equation
[O:1]=[C:2]([C:8]1[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=1)[CH2:3][CH2:4][C:5]([OH:7])=O.[NH:14]1[CH2:21][CH2:20][CH2:19][C@H:15]1[C:16]([OH:18])=[O:17]>>[N:10]1[CH:11]=[CH:12][CH:13]=[C:8]([C:2]([CH2:3][CH2:4][C:5]([N:14]2[CH2:21][CH2:20][CH2:19][C@H:15]2[C:16]([OH:18])=[O:17])=[O:7])=[O:1])[CH:9]=1

Participants

3

Reactant 2

HCID 4374-Oxo-4-(3-pyridyl)butyric acidHCID 145742L-Proline

Product 1

HCID 540535381-[3-(3-pyridylcarbonyl)propionyl]-L-proline

Procedure

As for Example 11, γ-oxo-3-pyridinebutyric acid is coupled to L-proline to give 1-[3-(3-pyridylcarbonyl)propionyl]-L-proline.

Sources & evidence

ORD record
ord-956c32c9ff484da89df781eada0f9cb6
Source dataset
uspto-grants-1982_08
Patent number
US04342689

Reaction notes

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