反应详情

As for Example 1, 1-[3-bromo-3-(2-thenoyl)propionyl]-L-proline (0.0085 mole) in 25 ml. of acetonitrile is added to a mixture of 0.015 mole of sodium methoxide and 0.015 mole of thiobenzoic acid in 25 ml. of acetontrile. The mixture is stirred at room temperature for 16 hours, one ml. of acetic acid is added and the solvent removed under reduced pressure. The residue is partitioned between dichloromethane and water containing acetic acid. The organic layer is separated, washed with water, dried over magnesium sulfate and the solvent removed under reduced pressure to give the product of the Example as a pale yellow glass.

1. customthe solvent removed under reduced pressure
2. customThe residue is partitioned between dichloromethane and water
3. additioncontaining acetic acid
4. customThe organic layer is separated
5. washwashed with water
6. dry with materialdried over magnesium sulfate
7. customthe solvent removed under reduced pressure
8. customto give the product of the Example as a pale yellow glass