HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → 1-[3-Acetylthio-3-(5-chloro-3-thenoyl)propionyl]-L-proline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | L-Proline | HCID 145742 | — |
| Reactant | HCID 20530004 | HCID 20530004 | — |
| Reactant | HCID 23700354 | HCID 23700354 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 1-[3-Acetylthio-3-(5-chloro-3-thenoyl)propionyl]-L-proline | HCID 54044067 | — |
Reaction Steps
As for Example 8, 3-(5-chloro-3-thenoyl)propionic acid is coupled to L-proline with 1,1'-carbonyldiimidazole. The coupled product is reacted with bromine in acetic acid and the brominated derivative is reacted with sodium thioacetate in acetonitrile to give the product of the Example as a glass.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04342690 |
| Source dataset | uspto-grants-1982_08 |
| ORD ID | ord-9c5f18ea9e40487192b5f5ec517f8a09 |
| Source note | uspto-grants-1982_08 |