Benzyl 4-oxopiperidine-1-carboxylate → Benzyl 4-[3-[[2-[[3-(trifluoromethyl)benzoyl]amino]acetyl]amino]pyrrolidin-1-yl]piperidine-1-carboxylate

HRID 665089Notes

Reaction equation

HRID 665089 reaction equation
[CH3:1][O:2][c:3]1[n:4][cH:5][c:6]([N:9]2[CH2:10][CH2:11][CH:12]([N:15]3[CH2:16][CH:17]([NH:20][C:21]([CH2:22][NH:23][C:24]([c:25]4[cH:26][c:27]([C:31]([F:32])([F:33])[F:34])[cH:28][cH:29][cH:30]4)=[O:35])=[O:36])[CH2:18][CH2:19]3)[CH2:13][CH2:14]2)[cH:7][cH:8]1.[CH3:54][O:55][c:56]1[n:57][cH:58][c:59]([N:60]2[CH2:61][CH2:62][C:63](=[O:64])[CH2:65][CH2:66]2)[cH:67][cH:68]1.[O:37]=[C:38]1[CH2:39][CH2:40][N:41]([C:44](=[O:45])[O:46][CH2:47][c:48]2[cH:49][cH:50][cH:51][cH:52][cH:53]2)[CH2:42][CH2:43]1>>[N:9]1([C:44](=[O:45])[O:46][CH2:47][c:48]2[cH:49][cH:50][cH:51][cH:52][cH:53]2)[CH2:10][CH2:11][CH:12]([N:15]2[CH2:16][CH:17]([NH:20][C:21]([CH2:22][NH:23][C:24]([c:25]3[cH:26][c:27]([C:31]([F:32])([F:33])[F:34])[cH:28][cH:29][cH:30]3)=[O:35])=[O:36])[CH2:18][CH2:19]2)[CH2:13][CH2:14]1

Participants

4

Reactant 3

HCID 643496Benzyl 4-oxopiperidine-1-carboxylateHCID 220002791-(6-Methoxypyridin-3-yl)piperidin-4-oneHCID 69398267N-[2-[[1-[1-(6-methoxypyridin-3-yl)piperidin-4-yl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide

Product 1

HCID 76618831Benzyl 4-[3-[[2-[[3-(trifluoromethyl)benzoyl]amino]acetyl]amino]pyrrolidin-1-yl]piperidine-1-carboxylate

Sources & evidence

ORD record
ord-e5fe018b835e42b0b84ee0d9f9e88867
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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