HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → 1-[3-(Benzoylthio)-3-(1-methyl-2-pyrrolylcarbonyl)propionyl]-L-proline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | Benzenecarbothioic acid, sodium salt (1:1) | HCID 23688990 | — |
| Reactant | 1-[3-bromo-(1-methyl-2-pyrrolylcarbonyl)propionyl]-L-proline | HCID 86738094 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 1-[3-(Benzoylthio)-3-(1-methyl-2-pyrrolylcarbonyl)propionyl]-L-proline | HCID 54334698 | — |
Reaction Steps
As for Example 1, the preceding compound is coupled to L-proline to give 1-[3-(1-methyl-2-pyrrolylcarbonyl)propionyl]-L-proline. The preceding compound (0.01 mole) is brominated with bromine (0.011 mole) in acetic acid and the resulting 1-[3-bromo-(1-methyl-2-pyrrolylcarbonyl)propionyl]-L-proline (0.01 mole) is reacted with sodium thiobenzoate as for Example 21 to give the product of the Example as a glass.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04342690 |
| Source dataset | uspto-grants-1982_08 |
| ORD ID | ord-864090ef948d434191529459a33d2f40 |
| Source note | uspto-grants-1982_08 |