3-(hydroxymethyl)-3-[2-hydroxy-5-(trifluoromethyl)phenyl]-1-pentyl-1,3-dihydro-2H-indol-2-one → 1'-pentyl-5-(trifluoromethyl)spiro[1-benzofuran-3,3'-indol]-2'(1'H)-one

HRID 665130Notes

Reaction equation

HRID 665130 reaction equation
[CH:29]1([CH2:30][CH2:31][N:32]2[c:33]3[c:34]([cH:35][cH:36][cH:37][cH:38]3)[C:39]([c:40]3[c:41]([OH:42])[cH:43][c:44]4[c:48]([cH:49]3)[O:47][CH2:46][O:45]4)([CH2:50][OH:51])[C:52]2=[O:53])[CH2:54][CH2:55]1.[OH:1][CH2:2][C:3]1([c:18]2[c:19]([OH:28])[cH:20][cH:21][c:22]([C:24]([F:25])([F:26])[F:27])[cH:23]2)[C:4](=[O:17])[N:5]([CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]21>>[O:1]1[CH2:2][C:3]2([C:4](=[O:17])[N:5]([CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[c:6]3[cH:7][cH:8][cH:9][cH:10][c:11]32)[c:18]2[c:19]1[cH:20][cH:21][c:22]([C:24]([F:25])([F:26])[F:27])[cH:23]2

Participants

3

Reactant 2

HCID 588724753-(hydroxymethyl)-3-[2-hydroxy-5-(trifluoromethyl)phenyl]-1-pentyl-1,3-dihydro-2H-indol-2-oneHCID 666425671-(2-cyclopropylethyl)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3-(hydroxymethyl)-1,3-dihydro-2H-indol-2-one

Product 1

HCID 592634221'-pentyl-5-(trifluoromethyl)spiro[1-benzofuran-3,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record
ord-767342c1e0484b638342204fe478025f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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