HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1'-Carbonyldiimidazole → 1-[3-(2-quinolylcarbonyl)propionyl]-L-proline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | L-Proline | HCID 145742 | — |
| Reactant | 3-(2-Quinolylcarbonyl)propionic acid | HCID 20530013 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-[3-(2-quinolylcarbonyl)propionyl]-L-proline | HCID 53777576 | — |
Reaction Steps
As for Example 6, 3-(2-quinolylcarbonyl)propionic acid (0.01 mole) is coupled to L-proline (0.011 mole) with 1,1'-carbonyldiimidazole (0.01 mole) in tetrahydrofuran to give 1-[3-(2-quinolylcarbonyl)propionyl]-L-proline. Bromination of the preceding compound and reaction of the resulting compound with sodium thioacetate gives the product of the Example.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04342690 |
| Source dataset | uspto-grants-1982_08 |
| ORD ID | ord-bc48d125118545e780e35edb4bd232e5 |
| Source note | uspto-grants-1982_08 |