Methanol → 1-(2-{4-[(2,3-Dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)amino]-2-methylpiperidin-1-yl}ethyl)-5,7-difluoroquinolin-2(1H)-one

HRID 665194Notes

Reaction equation

HRID 665194 reaction equation
[C:36]([O:37][BH-:38]([O:39][C:40](=[O:41])[CH3:42])[O:43][C:44](=[O:45])[CH3:46])(=[O:47])[CH3:48].[CH3:50][OH:51].[Cl:52][CH:53]([Cl:54])[CH3:55].[NH2:1][CH:2]1[CH2:3][CH:4]([CH3:23])[N:5]([CH2:8][CH2:9][n:10]2[c:11](=[O:22])[cH:12][cH:13][c:14]3[c:15]([F:21])[cH:16][c:17]([F:20])[cH:18][c:19]23)[CH2:6][CH2:7]1.[Na+:49].[O:24]1[CH2:25][CH2:26][O:27][c:28]2[cH:29][n:30][c:31]([CH:34]=[O:35])[cH:32][c:33]21>>[NH:1]([CH:2]1[CH2:3][CH:4]([CH3:23])[N:5]([CH2:8][CH2:9][n:10]2[c:11](=[O:22])[cH:12][cH:13][c:14]3[c:15]([F:21])[cH:16][c:17]([F:20])[cH:18][c:19]23)[CH2:6][CH2:7]1)[CH2:34][c:31]1[n:30][cH:29][c:28]2[c:33]([cH:32]1)[O:24][CH2:25][CH2:26][O:27]2

Participants

7

Reactant 6

HCID 887MethanolHCID 923Sodium ionHCID 63651,1-DichloroethaneHCID 2724942TriacetoxyborohydrideHCID 218736682,3-Dihydro[1,4]dioxino[2,3-c]pyridine-7-carbaldehydeHCID 66774568HCID 66774568, compound

Product 1

HCID 667740271-(2-{4-[(2,3-Dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)amino]-2-methylpiperidin-1-yl}ethyl)-5,7-difluoroquinolin-2(1H)-one

Sources & evidence

ORD record
ord-31f7b22263f044f9ade2b85e8b8507d7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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