HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine N-Oxide → Pyridine N-Oxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine N-Oxide | HCID 12753 | — |
| Reactant | L-Proline | HCID 145742 | — |
| Reactant | 4-Oxo-4-(2-pyridyl)butyric acid | HCID 2760269 | — |
| Product | Pyridine N-Oxide | HCID 12753 | — |
| Product | 1-[3-(2-pyridylcarbonyl)propionyl]-L-proline | HCID 54135146 | — |
Reaction Steps
As for Example 11, γ-oxo-2-pyridinebutyric acid, pyridine-1-oxide is coupled to L-proline to give 1-[3-(2-pyridylcarbonyl)propionyl]-L-proline, pyridine-1-oxide. Reaction of the preceding compound with bromine in acetic acid and reaction of the brominated compound with sodium thioacetate in acetonitrile gives the product of the Example as a glass.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04342691 |
| Source dataset | uspto-grants-1982_08 |
| ORD ID | ord-d1b93664865944cd9e1b8499dc1504f6 |
| Source note | uspto-grants-1982_08 |