反应详情

As for Example 21, 1-[3-bromo-3-(benzo[b]thien-3-ylcarbonyl)propionyl]-L-proline (0.01 mole) in 25 ml. of acetonitrile is added to a mixture of 0.01 mole of sodium methoxide and 0.015 mole of thiobenzoic acid in 25 ml. of acetonitrile. The mixture is stirred at room temperature for 16 hours, one ml. of acetic acid is added and the solvent is evaporated in vacuo. The residue is partitioned between dichloromehane and water containing acetic acid. The organic layer is separated, washed with water and dried over magnesium sulfate. The solvent is removed in vacuo to give the product of the Example as a yellow glass.

1. customthe solvent is evaporated in vacuo
2. customThe residue is partitioned between dichloromehane and water
3. additioncontaining acetic acid
4. customThe organic layer is separated
5. washwashed with water
6. dry with materialdried over magnesium sulfate
7. customThe solvent is removed in vacuo
8. customto give the product of the Example as a yellow glass