Potassium Cation → 7a-(2-Fluorophenyl)-5-(trifluoromethyl)-4,4a,5,7-tetrahydrofuro[3,4-d][1,3]thiazin-2-amine

HRID 665358Notes

Reaction equation

HRID 665358 reaction equation
[CH3:36][OH:37].[F:1][c:2]1[c:3]([C:8]23[N:9]=[C:10]([NH:21][C:22](=[O:23])[c:24]4[cH:25][cH:26][cH:27][cH:28][cH:29]4)[S:11][CH2:12][CH:13]2[CH:14]([C:17]([F:18])([F:19])[F:20])[O:15][CH2:16]3)[cH:4][cH:5][cH:6][cH:7]1.[K+:30].[K+:31].[O-:32][C:33]([O-:34])=[O:35]>>[F:1][c:2]1[c:3]([C:8]23[N:9]=[C:10]([NH2:21])[S:11][CH2:12][CH:13]2[CH:14]([C:17]([F:18])([F:19])[F:20])[O:15][CH2:16]3)[cH:4][cH:5][cH:6][cH:7]1

Participants

5

Reactant 4

HCID 813Potassium Cation2×HCID 887MethanolHCID 19660Carbonate IonHCID 70495546N-[7a-(2-fluorophenyl)-5-(trifluoromethyl)-4,4a,5,7-tetrahydrofuro[3,4-d][1,3]thiazin-2-yl]benzamide

Product 1

HCID 726717007a-(2-Fluorophenyl)-5-(trifluoromethyl)-4,4a,5,7-tetrahydrofuro[3,4-d][1,3]thiazin-2-amine

Sources & evidence

ORD record
ord-09fa645243fb4667ab97d42ea6592ba0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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