L-Proline → HCID 54021473, compound

HRID 66540Notes

Reaction equation

HRID 66540 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]([CH:13]=[CH:14][C:15]([OH:17])=O)=[O:12])=[CH:3]1.[NH:18]1[CH2:25][CH2:24][CH2:23][C@H:19]1[C:20]([OH:22])=[O:21]>>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]([CH:13]=[CH:14][C:15]([N:18]2[CH2:25][CH2:24][CH2:23][C@H:19]2[C:20]([OH:22])=[O:21])=[O:17])=[O:12])=[CH:3]1

Participants

3

Reactant 2

HCID 145742L-ProlineHCID 545738023-(1-Methyl-3-indolylcarbonyl)acrylic acid

Product 1

HCID 54021473HCID 54021473, compound

Procedure

As for Example 29, 3-(1-methyl-3-indolylcarbonyl)acrylic acid is coupled to L-proline to give 1-[3-(1-methyl-3-indolylcarbonyl)acryloyl]-L-proline.

Sources & evidence

ORD record
ord-b5a717684355426589fa1b7c0e631164
Source dataset
uspto-grants-1982_08
Patent number
US04342691

Reaction notes

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