4-Bromo-1-isoquinolinamine → 4-(8-((4-tert-butylpiperidin-1-yl)methyl)-9-methyl-6-morpholino-9H-purin-2-yl)isoquinolin-1-amine
Reaction equation
[Br:41][c:42]1[cH:43][n:44][c:45]([NH2:52])[c:46]2[cH:47][cH:48][cH:49][cH:50][c:51]12.[C:1]([CH3:2])([CH3:3])([CH3:4])[CH:5]1[CH2:6][CH2:7][N:8]([CH2:11][c:12]2[n:13]([CH3:40])[c:14]3[n:15][c:16]([Sn:27]([CH2:28][CH2:29][CH2:30][CH3:31])([CH2:32][CH2:33][CH2:34][CH3:35])[CH2:36][CH2:37][CH2:38][CH3:39])[n:17][c:18]([N:21]4[CH2:22][CH2:23][O:24][CH2:25][CH2:26]4)[c:19]3[n:20]2)[CH2:9][CH2:10]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[CH:5]1[CH2:6][CH2:7][N:8]([CH2:11][c:12]2[n:13]([CH3:40])[c:14]3[n:15][c:16](-[c:42]4[cH:43][n:44][c:45]([NH2:52])[c:46]5[cH:47][cH:48][cH:49][cH:50][c:51]45)[n:17][c:18]([N:21]4[CH2:22][CH2:23][O:24][CH2:25][CH2:26]4)[c:19]3[n:20]2)[CH2:9][CH2:10]1Participants
3
Sources & evidence
- ORD record
- ord-919038389a824bf486e13cb4a6816d4b
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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