5-methyl-1-[3-(trifluoromethyl)phenyl]-1H-pyrazole-4-carboxylic acid → N-[3-Cyano-4-(4-morpholinopiperidin-1-yl)phenyl]-1-(3-trifluoromethylphenyl)-5-methylpyrazole-4-carboxamide
Reaction equation
[F:1][C:2]([c:3]1[cH:4][c:5](-[n:9]2[n:10][cH:11][c:12]([C:15](=[O:16])[OH:17])[c:13]2[CH3:14])[cH:6][cH:7][cH:8]1)([F:18])[F:19].[NH2:20][c:21]1[cH:22][cH:23][c:24]([N:29]2[CH2:30][CH2:31][CH:32]([N:35]3[CH2:36][CH2:37][O:38][CH2:39][CH2:40]3)[CH2:33][CH2:34]2)[c:25]([C:26]#[N:27])[cH:28]1>>[F:1][C:2]([c:3]1[cH:4][c:5](-[n:9]2[n:10][cH:11][c:12]([C:15](=[O:17])[NH:20][c:21]3[cH:22][cH:23][c:24]([N:29]4[CH2:30][CH2:31][CH:32]([N:35]5[CH2:36][CH2:37][O:38][CH2:39][CH2:40]5)[CH2:33][CH2:34]4)[c:25]([C:26]#[N:27])[cH:28]3)[c:13]2[CH3:14])[cH:6][cH:7][cH:8]1)([F:18])[F:19]Participants
3
Sources & evidence
- ORD record
- ord-d3a51bfd6f734b309895cbf476766c91
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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