Dichloromethane → N-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)phenyl)-2-(4-methylpiperazin-1-yl)acetamide

HRID 665624Notes

Reaction equation

HRID 665624 reaction equation
[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([CH2:8][C:9](=[O:10])[NH:11][c:12]2[cH:13][c:14](-[c:18]3[n:19][c:20]4[cH:21][cH:22][cH:23][cH:24][c:25]4[c:26]([NH:28][c:29]4[cH:30][c:31]5[cH:32][n:33][n:34]([C:38]([O:39][C:40]([CH3:41])([CH3:42])[CH3:43])=[O:44])[c:35]5[cH:36][cH:37]4)[n:27]3)[cH:15][cH:16][cH:17]2)[CH2:6][CH2:7]1.[Cl:45][CH2:46][Cl:47]>>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([CH2:8][C:9](=[O:10])[NH:11][c:12]2[cH:13][c:14](-[c:18]3[n:19][c:20]4[cH:21][cH:22][cH:23][cH:24][c:25]4[c:26]([NH:28][c:29]4[cH:30][c:31]5[cH:32][n:33][nH:34][c:35]5[cH:36][cH:37]4)[n:27]3)[cH:15][cH:16][cH:17]2)[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 6344DichloromethaneHCID 59361937tert-butyl 5-(2-(3-(2-(4-methylpiperazin-1-yl)acetamido)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

Product 1

HCID 59361877N-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)phenyl)-2-(4-methylpiperazin-1-yl)acetamide

Sources & evidence

ORD record
ord-812d0368dd5f4768b41ebb4800f93cc1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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