HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-Bromo-5-chloro-2[(methylthio) (methoxy)acetyl]-3-(2-pyridyl)indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Sch 24937 | HCID 173465 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-Bromo-5-chloro-2[(methylthio) (methoxy)acetyl]-3-(2-pyridyl)indole | HCID 20530426 | — |
Reaction Steps
Add 2 ml of concentrated hydrochloric acid to 6-bromo-5-chloro-2[(methylsulfinyl)acetyl]-3-(2-pyridyl)indole (5.0 g) in 50 ml of methanol and 50 ml of tetrahydrofuran, warm the mixture to 60° for 2 hours. Cool, add water and the resulting solid is collected and dried to obtain 6-bromo-5-chloro-2[(methylthio) (methoxy)acetyl]-3-(2-pyridyl)indole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04342769 |
| Source dataset | uspto-grants-1982_08 |
| ORD ID | ord-76705779064d47da967d22936e4fe364 |
| Source note | uspto-grants-1982_08 |