Methanol → 1-(1,3-benzodioxol-5-yl)-N-[5-[[3-[tert-butyl(dimethyl)silyl]oxypyrrolidin-1-yl]-(2-chloro-4-fluorophenyl)methyl]-1,3-thiazol-2-yl]cyclopropane-1-carboxamide
Reaction equation
[BH4-:45].[C:31]([CH3:32])([CH3:33])([CH3:34])[Si:35]([O:36][CH:37]([CH2:38][CH:39]=[O:42])[CH2:41][Cl:40])([CH3:43])[CH3:44].[CH3:47][OH:48].[NH2:1][CH:2]([c:3]1[cH:4][n:5][c:6]([NH:8][C:9](=[O:10])[C:11]2([c:14]3[cH:15][c:16]4[c:17]([cH:21][cH:22]3)[O:18][CH2:19][O:20]4)[CH2:12][CH2:13]2)[s:7]1)[c:23]1[c:24]([Cl:30])[cH:25][c:26]([F:29])[cH:27][cH:28]1.[Na+:46].[OH2:49]>>[N:1]1([CH:2]([c:3]2[cH:4][n:5][c:6]([NH:8][C:9](=[O:10])[C:11]3([c:14]4[cH:15][c:16]5[c:17]([cH:21][cH:22]4)[O:18][CH2:19][O:20]5)[CH2:12][CH2:13]3)[s:7]2)[c:23]2[c:24]([Cl:30])[cH:25][c:26]([F:29])[cH:27][cH:28]2)[CH2:39][CH2:38][CH:37]([O:36][Si:35]([C:31]([CH3:32])([CH3:33])[CH3:34])([CH3:43])[CH3:44])[CH2:41]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-f9f5f98c9f684ba790b328f5c53dad72
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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