反应详情

A solution of 2-guanidino-4-(3-aminocyclohexyl)thiazole (0.5 g.) in boiling acetonitrile (25 ml.) was treated with 1,1-di(methylthio)-2-nitroethylene (0.35 g.) and the mixture heated under reflux for 7 hours. The reaction mixture was evaporated to dryness and the residue crystallised from methanol to give 1-[3-(2-guanidinothiazol-4-yl)cyclohexylamino]-1-methylthio-2-nitroethylene (0.5 g.) as a yellow solid. The n.m.r. spectrum in d6 dimethylsulphoxide included signals at 1.2-2.2(m) 3.3(s), 3.7(m), 6.27(s), 6.65(s) and 6.69(br s)

1. temperaturethe mixture heated
2. temperatureunder reflux for 7 hours
3. customThe reaction mixture was evaporated to dryness
4. customthe residue crystallised from methanol