Methanol → N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-hydroxypiperidin-1-yl)-1-isopropyl-1H-pyrazolo[3,4-b]pyridine-4-carboxamide

HRID 665892Notes

Reaction equation

HRID 665892 reaction equation
[BH4-:33].[CH3:1][c:2]1[c:3]([CH2:10][NH:11][C:12](=[O:13])[c:14]2[c:15]3[c:16]([n:17][c:18]([N:20]4[CH2:21][CH2:22][C:23](=[O:26])[CH2:24][CH2:25]4)[cH:19]2)[n:27]([CH:30]([CH3:31])[CH3:32])[n:28][cH:29]3)[c:4](=[O:9])[nH:5][c:6]([CH3:8])[cH:7]1.[CH3:35][OH:36].[Na+:34]>>[CH3:1][c:2]1[c:3]([CH2:10][NH:11][C:12](=[O:13])[c:14]2[c:15]3[c:16]([n:17][c:18]([N:20]4[CH2:21][CH2:22][CH:23]([OH:26])[CH2:24][CH2:25]4)[cH:19]2)[n:27]([CH:30]([CH3:31])[CH3:32])[n:28][cH:29]3)[c:4](=[O:9])[nH:5][c:6]([CH3:8])[cH:7]1

Participants

5

Reactant 4

HCID 887MethanolHCID 923Sodium ionHCID 28123BorohydrideHCID 68295699N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-6-(4-oxopiperidin-1-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide

Product 1

HCID 68350888N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-hydroxypiperidin-1-yl)-1-isopropyl-1H-pyrazolo[3,4-b]pyridine-4-carboxamide

Sources & evidence

ORD record
ord-c7bd364ec63a4ca78105cd793eaa853c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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