Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1) → 1-[2-Chloro-4-(2-morpholinoethoxy)phenyl]-1-butanone

HRID 66613Notes

Reaction equation

HRID 66613 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][CH2:10][N:11]([CH2:14][CH3:15])[CH2:12][CH3:13])[CH:5]=[CH:4][C:3]=1[C:16](=[O:20])[CH2:17][CH2:18][CH3:19].Cl.ClCCN1CC[O:28]CC1>>[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][CH2:10][N:11]2[CH2:12][CH2:13][O:28][CH2:15][CH2:14]2)[CH:5]=[CH:4][C:3]=1[C:16](=[O:20])[CH2:17][CH2:18][CH3:19]

Participants

3

Reactant 2

HCID 77210Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1)HCID 130523711-[2-Chloro-4-(2-diethylaminoethoxy)phenyl]-1-butanone

Product 1

HCID 204971681-[2-Chloro-4-(2-morpholinoethoxy)phenyl]-1-butanone

Procedure

This compound is prepared by essentially the same procedure as described in Example 1 Step A except that the 2-diethylaminoethyl chloride hydrochloride of Example 1, Step A is replaced by an equimolecular quantity of N-(2-chloroethyl)morpholine hydrochloride. The product is obtained as a colorless oil upon distillation in vacuo (0.3 mm.).

Workup

  1. customThis compound is prepared by essentially the same procedure
  2. customThe product is obtained as a colorless oil upon distillation in vacuo (0.3 mm.)

Sources & evidence

ORD record
ord-50fe5b40ef434616b743efc448ba991b
Source dataset
uspto-grants-1982_08
Patent number
US04342782

Reaction notes

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