反应详情

A mixture of 62.5 g. of ethyl 3-phenyl-3-(4-nitrophenyl)propenoate, 100 ml. of ethanol and 300 ml. of 1.5 N potassium hydroxide was heated on a steam bath for 1 hour. To the cooled reaction mixture was added 800 ml. of water and 500 ml. of ethyl acetate, and then the ethyl acetate layer was removed. The aqueous layer was acidified, and the solid which precipitated was collected by filtration. This solid was recrystallized from toluene and then from carbon tetrachloride to give 22 g. of the title compound, m.p. 188°-189° C.

1. additionA mixture of 62.5 g
2. customTo the cooled reaction mixture
3. additionwas added 800 ml
4. customof ethyl acetate, and then the ethyl acetate layer was removed
5. customthe solid which precipitated
6. filtrationwas collected by filtration
7. customThis solid was recrystallized from toluene
8. customfrom carbon tetrachloride to give 22 g