Hydrochloric Acid → 1-Fluoro-3-(4-methoxyphenyl)-2-propanone

Participants

Reaction Steps

2-Ethoxy-1-fluoro-3-(4-methoxyphenyl)prop-2-ene (5 g, 0.024 mol) is stirred with a saturated solution of hydrogen chloride in diethyl ether (40 ml) overnight. Water (18 ml) is added and the stirring is continued for another 3 hours. The ether layer is separated, washed with water, dried (MgSO4), and filtered. Concentration of the solvent affords 1-fluoro-3-(4-methoxyphenyl)-2-propanone (4.2 g); NMR (CDCl3): 6.7-7.3 ppm (4H, m), 4.8 ppm (2H, J=48 Hz), 3.7-3.9 ppm (5H, m).

Provenance & Evidence