alpha-[1-(Phenylmethyl)-4-piperidinylidene]-2-thiopheneacetonitrile → 1-(Phenylmethyl)-alpha-(2-thienyl)-4-piperidineacetonitrile

Participants

Reaction Steps

A mixture of 70 parts of α-[1-(phenylmethyl)-4-piperidinylidene]-2-thiopheneacetonitrile in 800 parts of methanol is hydrogenated at normal pressure and at room temperature with 10 parts of palladiumon charcoal catalyst 10%. After the calculated amount of hydrogen is taken up, the catalyst is filtered off and the filtrate is evaporated, yielding 70 parts of 1-(phenylmethyl)-α-(2-thienyl)-4-piperidineacetonitrile as a residue.

Provenance & Evidence